There are contraindications! Be sure to consult your doctor before taking any medication!
Gabatrex is an antiepileptic drug. Chemical structure is similar to GABA fulfilling the function of the inhibitory neurotransmitter in the CNS. It is believed that the mechanism of action of Gabatrex is different from other anticonvulsants acting through GABA synapses (including valproate, barbiturates, benzodiazepines, inhibitors of GABA-transaminase, inhibitors of GABA capture, GABA agonists and prodrugs of GABA). In in vitro studies showed that Gabatrex is characterized by the presence of a new peptide binding sites in the brain tissues of rats, including the hippocampus and cerebral cortex, which may be relevant to the anticonvulsant activity of Gabatrex and its derivatives. Gabatrex in clinically relevant concentrations is not associated with other conventional drugs and neurotransmitter receptors in the brain.
The final mechanism of action of Gabatrex is not defined.
Gabatrex is absorbed from the gastrointestinal tract. After oral administration of Gabatrex Cmax in plasma achieved within 2-3 hours. The absolute bioavailability of approximately 60%. Taking of this medication in conjunction with food (including a high-fat) does not affect the pharmacokinetics of gabapentin.
Gabatrex is not bound to plasma proteins and has Vd 57.7 l.
Gabatrex is excreted only by the kidneys. Signs of biotransformation of Gabatrex in the human body were not found.
Gabatrex is removed from plasma by hemodialysis.
The concentrations of Gabatrex in the plasma of children were similar to those of adults.
Why is Gabatrex prescribed?
Treatment of neuropathic pain in adults over the age of 18 years; monotherapy of partial seizures with secondary generalization and without its fot children and adults older than 12 years; as an adjunct in the treatment of partial seizures with secondary generalization and without its for adults and children aged 3 years and older.
Dosage and administration
Dosing regimen of Gabatrex is individual, depending on the indications and treatment regimens.
Dermatological reactions: maceration of the skin, acne, itching, rash.
Other: back pain, fatigue, peripheral edema, impotence, fatigue, malaise, swelling of the face, increase in body weight, accidental injury, asthenia, flu-like syndrome, fluctuations in blood glucose in children - a viral infection, otitis media.
Hypersensitivity to gabapentin.
Using during pregnancy and breastfeeding
Adequate and well-controlled studies on the safety of Gabatrex during pregnancy and lactation in humans has not been conducted. If necessary use Gabatrex during pregnancy and lactation patients should carefully weigh the potential benefits of therapy for the mother and the potential risk to the fetus or infant.
Gabatrex is excreted in breast milk. When this drug used in the lactation period, the character of the action of Gabatrex on the infant is not defined.
Category effects on the fetus by FDA - C.
Abrupt discontinuation of therapy by anticonvulsant drugs in patients with partial seizures may provoke a convulsive status. If necessary to reduce the dose of Gabatrex, to cancel or replace it with an alternative means it should be phased over a minimum of 1 week.
Gabatrex is not an effective drug for treatment of absence seizures.
For patients with impaired renal function and patients in hemodialysis it requires correction of dosing regimen. Elderly patients may require correction of the dosing regimen of Gabatrex due to the fact that such patients may decrease renal clearance.
The efficacy and safety of neuropathic pain treatment in patients under age 18 is not defined.
During the period of treatment it is necessary to avoid taking alcohol.
Prior to determining individual response to treatment the patient should refrain from potentially dangerous activities coupled with the need to focus and improve the speed of psychomotor reactions.
Gabatrex drug interactions
Simultaneous administration of Gabatrex with:
antacids reduces the absorption of Gabatrex from the gastrointestinal tract.
felbamate may increase its T1/2.
described a case of increasing the concentration of phenytoin in blood plasma.
Gabatrex in case of emergency / overdose
There was reported an acute overdose while taking 49 g of gabapentin. Symptoms: double vision, slurred speech, drowsiness, lethargy, diarrhea.
Treatment: maintenance therapy, hemodialysis.
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: